Hydrophilic matrices are prolonged-release tablets. They are used worldwide within the pharmaceutical industry to design new types of medicines. They are easy to manufacture, and simple to design - you simply include a water-swelling polymer into a normal tablet formulation – but their drug release processes are complex, and the mechanisms by which other ingredients and the stomach environment influences their behaviour, is not well understood.
In this project you will be designing new types of matrices for new medical conditions, and discovering what happens inside the matrix as it releases drug. We will compare the industry standard polymer, HPMC, with another food polymer to investigate if we can control the sometimes unpredictable changes that occur in the matrix in response to their external environment. Experimental work will be done in the lab - there is no animal or human testing involved - and work will include using our novel imaging developed in the group.The project is with a major pharmaceutical company so you’ll have interactions with scientists of the industrial sponsor and their labs. The training and insight in this key technology that you will gain from this PhD, will give you a competitive advantage when applying for a career in the pharmaceutical industry, or related companies. A degree in pharmacy, material science, food science, polymer science, chemistry or chemical engineering would be useful, and industrial experience an advantage, but not essential. The project is only available to EU/UK graduates.
Funding information
Funding applies to:
EU applicants (including UK)
Contacts and how to apply
Academic contact:
For more details contact: Dr Colin Melia , Associate Professor, +44 (0)115-9515032 (direct)
colin.melia@nottingham.ac.uk
http://www.nottingham.ac.uk/Pharmacy/People/colin.melia
Administrative contact and how to apply:
To apply contact:
Mrs C MacLeod Christina.Macleod@nottingham.ac.uk
In this project you will be designing new types of matrices for new medical conditions, and discovering what happens inside the matrix as it releases drug. We will compare the industry standard polymer, HPMC, with another food polymer to investigate if we can control the sometimes unpredictable changes that occur in the matrix in response to their external environment. Experimental work will be done in the lab - there is no animal or human testing involved - and work will include using our novel imaging developed in the group.The project is with a major pharmaceutical company so you’ll have interactions with scientists of the industrial sponsor and their labs. The training and insight in this key technology that you will gain from this PhD, will give you a competitive advantage when applying for a career in the pharmaceutical industry, or related companies. A degree in pharmacy, material science, food science, polymer science, chemistry or chemical engineering would be useful, and industrial experience an advantage, but not essential. The project is only available to EU/UK graduates.
Funding information
Funding applies to:
EU applicants (including UK)
Contacts and how to apply
Academic contact:
For more details contact: Dr Colin Melia , Associate Professor, +44 (0)115-9515032 (direct)
colin.melia@nottingham.ac.uk
http://www.nottingham.ac.uk/Pharmacy/People/colin.melia
Administrative contact and how to apply:
To apply contact:
Mrs C MacLeod Christina.Macleod@nottingham.ac.uk
